In simple terms it ain't that simple. The marks works like a vernier calipers, it is a measurement of the length of the sight. What amount it moves the impact of the bullet, depends on the round, the velocity and bullet weight of the round and even the length of the barrel. There is not really a simple answer.
For most folks trial and error at know ranges will help one learn how to adjust the sight. Most of the old timers kept notes as to load and range, the vernier makes know settings with known ranges and known loads repeatable.