.45 Colt

[Chance]

I think I have my Uberti Colt Burgess rifle about ready to roll so looking for your pet loads for the ,45 Colt cartridge. CAS-type loads for up to 100 yards. Powders available at present are Unique, Trail Boss and VV 32C (Tin Star). Bullet is a lead RNFP 250 grains.

Chance

[Baltimore Ed]

My Marlin Cowboy with a 24 inch oct bbl likes 5.2 gr of clays or clay dot under a 225-250 gr coated or lead bullet. I don't think I've ever shot it that fer though. I use VV tin star in my .30-40 Krag.  Good luck on your load development.

[Coffinmaker]

My rifles like 18Gr 3f APP, topped with Cream-0-Wheat, under a 200Gr RNFP.  Of course this information presents no actual useful information to the OP.  Therefore, the foregoing may well be ignored and written up as SPAM.  I won't be at all insulted.  Nor Mollified.  Does NOT play well with "Others."  Sure I do.  Sometimes.  Once in a while??  On Thursdays anyway.

[Coal Creek Griff]

Unique has been a "classic" smokeless powder for the .45 Colt for a lot of years and it works for me.  For load specifics, check a number of reliable sources and use caution. 

CC Griff

[Sagebrush Burns]

I like Unique for 45 Colt loads.  With the 250 grain bullet my cowboy load is 7.0 grains for 825 fps in my 7 1/2" revolverss and 1025 fps in my 20" carbines.  For a bit stouter load I use 8.5 grains for 900+ fps in my 5 1/2" revolvers.

[greenjoytj]

I think I have my Uberti Colt Burgess rifle about ready to roll so looking for your pet loads for the ,45 Colt cartridge. CAS-type loads for up to 100 yards. Powders available at present are Unique, Trail Boss and VV 32C (Tin Star). Bullet is a lead RNFP 250 grains.

Chance

Since you have Unique on hand I recommend you start with that powder.  Check load manuals in print or online for load data. 
If your shooting to 100 yds I would look for loads towards the maximum end of the charge weight range in order to flatten the rainbow trajectory as much as possible.   Also look a Hodgdon's CFE-Pistol powder this powder has the 45 Colt bullets moving out at the highest MV of all the Hodgdon's powders listed in the online guide.   I've been using CFE-P at 9.0 grs. in my 45 Colt Ruger New Vaqueros.  My load is .2 grs below maximum.  Hodgdon shows the max load is at 13,000 PSI so there is a little wiggle room in load development if your rifle is strong enough to make a tiny step over the 14,000 PSI threshold.    CFE-P was the first powder I purchased for loading 45 Colt and have only just recently bought some Hodgdon Universal for those days when I want to keep the MV  in the 750 to 800 fps zone.
Also with CFE-P at 9 grs it fills the 45 Colt case up enough to easily visually detect a double charge.  I think that is a good feature to have in a pistol powder.   Unlike Hodgdon's Titegroup which makes a double charge visually undetectable in a big deep cartridge case.

[Chance]

Thanks for the suggestions, fellas. 7grs. Unique does pretty good at 25 yards. Will work up something for the longer distance in a couple of weeks.

greenjoytj, we are limited in our choice of American powders since June 1st this years when many were outlawed due to European legislation. Sooner we get out of that club the better.

[R.M. Conversion]

Unique works well.  If you want to try a new powder, I've also had great accuracy success with HP-38 in .45 Colt.