45 acp in a vaquero

[BlaiseNSaddles]

I have the birdshead grip 45LC vaqueros which I guess are now old style (but wasn't there one older yet?).

Anyway,  periodically I see some Blackhawk .45 ACP cylinders show up on ebay and was wondering if they might fit the Vaqueros.  The frame looks like it is more or less the same.

[Mustang Gregg]

They'd most likely fit in yer Vaquero.  The diameter & spacin' are the same.
They'd probably shoot.
But they may have a cylinder to barrel gap that might be too big or small.
Seen it done afore.