During the 72 hours after he made his assassination decision on April 11, Booth hurriedly organized Powell, Atzerodt and Herold for action on April 14. Booth was to kill Lincoln at Ford's Theater. Powell was to kill Secretary of State William Seward at home and Herold was to assist him. Atzerodt was to kill Vice President Andrew Johnson. All were to strike at 10:15 p.m.
"Before he went into Ford's theatre," said Boyle, "Booth stopped in a saloon along the side of the theater. As he was having a drink, someone in there recognized him and said, 'You're not the actor your father was,' Booth's answer was 'When I leave the stage, I'll be the most famous man in America.'" A short time later, sneaking into the President's theater box, he shot Lincoln in the head at point-blank range.
Simultaneously, Lewis Thornton Powell and David Herold arrived at the home of Secretary Seward, who had helped write and had signed the Emancipation Proclamation. Herold remained outside with the horses as Powell went to the front door. Carrying a Whitney Navy revolver and a 12-inch Bowie knife, he pushed past a servant and was confronted on the stairs by Seward's son, Frederick. Powell tried to shoot him in the head at close range but the revolver would not fire, so he beat him across the head with it. As he entered the elder Seward's room, Powell fought with both a male nurse and Seward's daughter before leaping on the bed and slashing the Secretary of State multiple times with the Bowie knife. On his way out of the building, he fought with both Seward's second son and a State Department courier, whose throat he slashed.
But once out on the street, he found himself alone. Herold, who was supposed to guide Powell out of the city, had heard all the noise and run away. Powell wandered around Washington for days, hiding in the Congressional cemetery at night, where he slept in a tree.
Meanwhile, George Atzerodt, armed with a gun, had checked into Washington's Kirkwood House where the Vice President was also staying. Before the appointed attack time, Atzerodt began drinking in the hotel bar. Drunk and unable to bring himself to actually carry out the murder, he wandered the streets of the capital for the rest of the night.