I really enjoy my .50 Express guns but I still think the .45-75 is a better hunting round, with all the boom and thrill of the larger Express caliber. I must admit that just saying the words .50 Express conjure up all kinds of excitement, but for me the .45-75 WCF does the same thing. When I was 15 years old, I bought my first '76. It was a great carbine in .45-75. I also bought from the same man, my first "Centennial" box of Winchester .45-75 ammunition. I shot that gun for many years using .348 brass, but when my wife and I got married we needed the money, so my carbine went down the road. I still have that original box of ammunition.
As a hunting round, it is very capable for any game you can find in North American from coyotes to moose. However, it is NOT a long range cartridge and you must stay within the ranges it was designed for. I shot my first buffalo with a deluxe pistol grip gun in .45-75 about 10 years ago. I loaded ammo with an original Winchester mold and tong tool and used 69 grains of 2F black. My brass is reformed .348 cases and this is about all they will hold. I took one off hand shot, which hit the animal low and just behind the left elbow. The bullet cut through the top of the heart and stopped just under the hide, low on the right shoulder. The buffalo took one step, dropped like a rock and never moved a muscle. The shot was 124 yards on a range finder. That was the first time I realized what a potent cartridge it really was.
Adios,
Buck