Howdy, Pard,
This is a question with two basic answers: Yes! and No!
Obviously, the "Yes!" answer is that it can and has been done without problems by a number of people, including Your Obedient Servant. If the gun is in good shape (which can be DIFFICULT to determine conclusively), and one sticks to BP or a substitute, you MAY be alright!
On the other hand, the "No!" answer is based on the fact that these guns are 142 years OLD, and not only was the art and science of metallurgy in its infancy in those days, but one has to contend with potential corrosion problems weakening the receiver and the barrel, possibly to the point of failure! I'm not sure if non-destructive testing, such as magnetic partical testing, X-ray, etc., would detect such problems or not, and the cost and locating a testing lab might be cost-prohibitive.
I have personally not fired my antique guns lately mainly out of respect for their age, but I might shoot a few rounds now and then.
For continuous useage, I would recommend a replica! Probably not the answer you wanted...if it is a definitive answer at all, but that's MHO!
Ride careful, Pard!