When I first bought my Henry in .45, I needed more cases so I bought a few boxes of Alabama Ammo's JHP. I figured they has Starline cases and the price was pretty cheap. Velocity was stated on the box at 1050, but I can't verify, seemed like a pretty mild load... Anyhow, it occurred to me that hunting with that Henry would be fun, so I fired a few at 100. The sights make it difficult, but from the bench, three five round groups were hanging between 1 3/4" - 2". I know there isn't a whole lot you can do with the trigger on the Henry, but I think with a little finer sight picture (perhaps the Smith Ladder Sight) would make this easy with the right load. I've been doing a lot of work on my .45 loads recently, and I'm having great success with jacketed bullets. The lead loads are coming along, but slowly. I'm finding a good crimp is key. I'm not a CAS shooter, I just enjoy period arms, so I don't know what you require, but in lead, I'm finding 200gr for smokeless, and 250 for black is giving good results. Ok, I'm running on here, but in short, it is indeed quite possible.